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Non-canonical inflammasome activation targets caspase-11

Author

Listed:
  • Nobuhiko Kayagaki

    (Genentech Inc.)

  • Søren Warming

    (Genentech Inc.)

  • Mohamed Lamkanfi

    (VIB
    Ghent University)

  • Lieselotte Vande Walle

    (VIB
    Ghent University)

  • Salina Louie

    (Genentech Inc.)

  • Jennifer Dong

    (Genentech Inc.)

  • Kim Newton

    (Genentech Inc.)

  • Yan Qu

    (Genentech Inc.)

  • Jinfeng Liu

    (Genentech Inc.)

  • Sherry Heldens

    (Genentech Inc.)

  • Juan Zhang

    (Genentech Inc.)

  • Wyne P. Lee

    (Genentech Inc.)

  • Merone Roose-Girma

    (Genentech Inc.)

  • Vishva M. Dixit

    (Genentech Inc.)

Abstract

Key role for caspase-11 in innate immunity It has long been presumed that caspase-11 is pro-inflammatory because of its homology to caspase-1, but its actual role has been enigmatic. Vishva Dixit and co-workers now report a crucial role for caspase-11 in inflammasome activation by various pathogenic Gram-negative bacteria, and show that lipopolysaccharide toxicity depends on caspase-11 — not on caspase-1 as previously thought. This work highlights a pro-inflammatory role for caspase-11 in the innate immune response to bacterial infections.

Suggested Citation

  • Nobuhiko Kayagaki & Søren Warming & Mohamed Lamkanfi & Lieselotte Vande Walle & Salina Louie & Jennifer Dong & Kim Newton & Yan Qu & Jinfeng Liu & Sherry Heldens & Juan Zhang & Wyne P. Lee & Merone Ro, 2011. "Non-canonical inflammasome activation targets caspase-11," Nature, Nature, vol. 479(7371), pages 117-121, November.
    • Handle: RePEc:nat:nature:v:479:y:2011:i:7371:d:10.1038_nature10558
    DOI: 10.1038/nature10558
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