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Structure of human mitochondrial RNA polymerase

Author

Listed:
  • Rieke Ringel

    (Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25)

  • Marina Sologub

    (University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, 2 Medical Center Dr)

  • Yaroslav I. Morozov

    (University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, 2 Medical Center Dr)

  • Dmitry Litonin

    (Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25
    University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, 2 Medical Center Dr)

  • Patrick Cramer

    (Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25)

  • Dmitry Temiakov

    (University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, 2 Medical Center Dr)

Abstract

A mitochondrial polymerase The transcription of the mitochondrial genome is carried out by a single-subunit RNA polymerase (mtRNAP), which is distantly related to the RNAP of bacteriophage T7. Unlike T7 RNAP, the mtRNAP requires additional transcription factors (TFAM and TFB2M) for transcription initiation. The crystal structure of human mtRNAP has now been determined, revealing novel domains and mechanistic adaptations that explain the requirement for TFAM and TFB2M. These findings provide insights into the evolution of polymerases from simple self-sufficient enzymes to large multi-subunit complexes.

Suggested Citation

  • Rieke Ringel & Marina Sologub & Yaroslav I. Morozov & Dmitry Litonin & Patrick Cramer & Dmitry Temiakov, 2011. "Structure of human mitochondrial RNA polymerase," Nature, Nature, vol. 478(7368), pages 269-273, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7368:d:10.1038_nature10435
    DOI: 10.1038/nature10435
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    Cited by:

    1. Lindsey Haute & Emily O’Connor & Héctor Díaz-Maldonado & Benjamin Munro & Kiran Polavarapu & Daniella H. Hock & Gautham Arunachal & Alkyoni Athanasiou-Fragkouli & Mainak Bardhan & Magalie Barth & Domi, 2023. "TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Jamie J Arnold & Suresh D Sharma & Joy Y Feng & Adrian S Ray & Eric D Smidansky & Maria L Kireeva & Aesop Cho & Jason Perry & Jennifer E Vela & Yeojin Park & Yili Xu & Yang Tian & Darius Babusis & Ona, 2012. "Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides," PLOS Pathogens, Public Library of Science, vol. 8(11), pages 1-12, November.
    3. Tin-Yan Koo & Hinyuk Lai & Daniel K. Nomura & Clive Yik-Sham Chung, 2023. "N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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