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The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Author

Listed:
  • Yue Zhao

    (Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College
    National Institute of Biological Sciences)

  • Jieling Yang

    (Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College
    National Institute of Biological Sciences)

  • Jianjin Shi

    (National Institute of Biological Sciences)

  • Yi-Nan Gong

    (National Institute of Biological Sciences)

  • Qiuhe Lu

    (National Institute of Biological Sciences)

  • Hao Xu

    (National Institute of Biological Sciences)

  • Liping Liu

    (National Institute of Biological Sciences)

  • Feng Shao

    (National Institute of Biological Sciences)

Abstract

Pathogen specificity in innate immunity The inflammasomes are multiprotein complexes involved in innate immunity, and induce an immune response to pathogenic microbes by activating the caspase 1 protease. Two groups now report that the intracellular receptors known as NAIPs (NLR family, apoptosis inhibitory proteins), previously thought to have an auxiliary role in recognizing microbial proteins, are in fact central to the process. Eric Kofoed and Russell Vance, and Feng Shao and colleagues, show that different members of the NAIP family bind to different bacterial ligands, including bacterial flagellin and a conserved bacterial type III secretion system rod protein.

Suggested Citation

  • Yue Zhao & Jieling Yang & Jianjin Shi & Yi-Nan Gong & Qiuhe Lu & Hao Xu & Liping Liu & Feng Shao, 2011. "The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus," Nature, Nature, vol. 477(7366), pages 596-600, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7366:d:10.1038_nature10510
    DOI: 10.1038/nature10510
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