IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v477y2011i7365d10.1038_nature10440.html
   My bibliography  Save this article

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

Author

Listed:
  • Mohan Viswanathan

    (Massachusetts Institute of Technology)

  • Leonard Guarente

    (Massachusetts Institute of Technology)

Abstract

Arising from H. A. Tissenbaum & L. Guarente Nature 410, 227–230 (2001)10.1038/35065638 Tissenbaum and Guarente1 identified the first metazoan Sir2 homologue shown to affect lifespan, Caenorhabditis elegans sir-2.1. Independent transgenic lines harbouring extrachromosomal DNA arrays containing sir-2.1 and the dominant transgene marker rol-6(su1006) were reported to extend mean lifespan between 15% and 50%1. Similar extensions in mean lifespan were also found for lines in which the sir-2.1 transgenic arrays were integrated into the genome following γ-irradiation1. However, the extension of lifespan was overestimated in a high-copy sir-2.1 transgene-containing worm strain because of an unlinked mutation.

Suggested Citation

  • Mohan Viswanathan & Leonard Guarente, 2011. "Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes," Nature, Nature, vol. 477(7365), pages 1-2, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7365:d:10.1038_nature10440
    DOI: 10.1038/nature10440
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10440
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10440?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:477:y:2011:i:7365:d:10.1038_nature10440. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.