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Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA

Author

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  • Leo Kurian

    (Institute for Genetics, University of Cologne, Cologne Biocenter, Zülpicher Strasse 47a
    Present addresses: Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037-1099, USA (L.K.); Department for Cell and Molecular Biology, Karolinska Institutet, Von Eulers väg 3, S-17177 Stockholm, Sweden (D.G.).)

  • R. Palanimurugan

    (Institute for Genetics, University of Cologne, Cologne Biocenter, Zülpicher Strasse 47a)

  • Daniela Gödderz

    (Institute for Genetics, University of Cologne, Cologne Biocenter, Zülpicher Strasse 47a
    Present addresses: Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037-1099, USA (L.K.); Department for Cell and Molecular Biology, Karolinska Institutet, Von Eulers väg 3, S-17177 Stockholm, Sweden (D.G.).)

  • R. Jürgen Dohmen

    (Institute for Genetics, University of Cologne, Cologne Biocenter, Zülpicher Strasse 47a)

Abstract

Polyamines give antizyme the slip Ornithine decarboxylase (ODC), the rate-limiting enzyme in the biosynthesis of polyamines, is regulated by an antizyme (OAZ). Polyamines induce antizyme expression by promoting ribosomal frame-shifting within the OAZ messenger RNA (mRNA). Although it was presumed that the polyamines interacted with either the fully transcribed mRNA or the ribosome itself, Kurian et al. have found that the regulation occurs through the interaction of polyamines with the nascent OAZ polypeptide, to inhibit ribosome stalling and promote its translation.

Suggested Citation

  • Leo Kurian & R. Palanimurugan & Daniela Gödderz & R. Jürgen Dohmen, 2011. "Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA," Nature, Nature, vol. 477(7365), pages 490-494, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7365:d:10.1038_nature10393
    DOI: 10.1038/nature10393
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