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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

Author

Listed:
  • Camilla Burnett

    (Evolution and Environment, University College London)

  • Sara Valentini

    (Evolution and Environment, University College London)

  • Filipe Cabreiro

    (Evolution and Environment, University College London)

  • Martin Goss

    (Evolution and Environment, University College London)

  • Milán Somogyvári

    (Semmelweis University)

  • Matthew D. Piper

    (Evolution and Environment, University College London)

  • Matthew Hoddinott

    (Evolution and Environment, University College London)

  • George L. Sutphin

    (University of Washington
    Molecular and Cellular Biology Program, University of Washington)

  • Vid Leko

    (Fred Hutchinson Cancer Research Center)

  • Joshua J. McElwee

    (Evolution and Environment, University College London)

  • Rafael P. Vazquez-Manrique

    (Inserm, Unit 894, Laboratory of Neuronal Cell Biology and Pathology
    Université Paris Descartes)

  • Anne-Marie Orfila

    (Inserm, Unit 894, Laboratory of Neuronal Cell Biology and Pathology
    Université Paris Descartes)

  • Daniel Ackerman

    (Evolution and Environment, University College London)

  • Catherine Au

    (Evolution and Environment, University College London)

  • Giovanna Vinti

    (Evolution and Environment, University College London)

  • Michèle Riesen

    (Evolution and Environment, University College London)

  • Ken Howard

    (MRC Laboratory for Molecular Cell Biology, University College London)

  • Christian Neri

    (Inserm, Unit 894, Laboratory of Neuronal Cell Biology and Pathology
    Université Paris Descartes)

  • Antonio Bedalov

    (Fred Hutchinson Cancer Research Center)

  • Matt Kaeberlein

    (University of Washington
    Molecular and Cellular Biology Program, University of Washington)

  • Csaba Sőti

    (Semmelweis University)

  • Linda Partridge

    (Evolution and Environment, University College London
    Max Planck Institute for Biology of Ageing, Gleueler Strasse 50a)

  • David Gems

    (Evolution and Environment, University College London)

Abstract

Sirtuin activity revisited Overexpression of sirtuins has been reported to increase lifespan in Caenorhabditis elegans and Drosophila melanogaster. The effects of dietary restriction on the lifespan of flies have also been reported to be Sir2-dependent. Here it is shown that these findings are attributable to the confounding effects of genetic background. This work suggests that the life-extending effect of sirtuin overexpression may be limited to yeast, and also supports studies in yeast and C. elegans that show that the effects of dietary restriction are not mediated by sirtuins.

Suggested Citation

  • Camilla Burnett & Sara Valentini & Filipe Cabreiro & Martin Goss & Milán Somogyvári & Matthew D. Piper & Matthew Hoddinott & George L. Sutphin & Vid Leko & Joshua J. McElwee & Rafael P. Vazquez-Manriq, 2011. "Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila," Nature, Nature, vol. 477(7365), pages 482-485, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7365:d:10.1038_nature10296
    DOI: 10.1038/nature10296
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