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Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

Author

Listed:
  • Daeho Park

    (Center for Cell Clearance, University of Virginia
    Beirne B. Cater Center for Immunology Research, University of Virginia)

  • Claudia Z. Han

    (Center for Cell Clearance, University of Virginia
    Beirne B. Cater Center for Immunology Research, University of Virginia
    University of Virginia)

  • Michael R. Elliott

    (Center for Cell Clearance, University of Virginia
    Beirne B. Cater Center for Immunology Research, University of Virginia)

  • Jason M. Kinchen

    (Center for Cell Clearance, University of Virginia
    Beirne B. Cater Center for Immunology Research, University of Virginia
    University of Virginia)

  • Paul C. Trampont

    (Center for Cell Clearance, University of Virginia
    Beirne B. Cater Center for Immunology Research, University of Virginia)

  • Soumita Das

    (University of Virginia)

  • Sheila Collins

    (Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute)

  • Jeffrey J. Lysiak

    (University of Virginia)

  • Kyle L. Hoehn

    (University of Virginia)

  • Kodi S. Ravichandran

    (Center for Cell Clearance, University of Virginia
    Beirne B. Cater Center for Immunology Research, University of Virginia
    University of Virginia)

Abstract

How phagocytes keep their appetite When a phagocyte engulfs a dying cell, it essentially doubles its cellular contents, yet phagocytes are capable of ingesting several apoptotic cells one after the other. The factors regulating this impressive engulfment capacity are not well understood. Kodi Ravichandran and colleagues show here that the mitochondrial membrane protein Ucp2, which is known to be linked to metabolic diseases and atherosclerosis, is critically important to engulfment capacity.

Suggested Citation

  • Daeho Park & Claudia Z. Han & Michael R. Elliott & Jason M. Kinchen & Paul C. Trampont & Soumita Das & Sheila Collins & Jeffrey J. Lysiak & Kyle L. Hoehn & Kodi S. Ravichandran, 2011. "Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein," Nature, Nature, vol. 477(7363), pages 220-224, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7363:d:10.1038_nature10340
    DOI: 10.1038/nature10340
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