IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v477y2011i7362d10.1038_nature10331.html
   My bibliography  Save this article

Protection of repetitive DNA borders from self-induced meiotic instability

Author

Listed:
  • Gerben Vader

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Hannah G. Blitzblau

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Mihoko A. Tame

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Jill E. Falk

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center
    Present addresses: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA (J.E.F.) ; Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA (A.H.).)

  • Lisa Curtin

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center
    Somerville High School)

  • Andreas Hochwagen

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center
    Present addresses: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA (J.E.F.) ; Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA (A.H.).)

Abstract

Preventing DNA injury in meiosis Breakages in repetitive ribosomal DNA (rDNA) sequences can lead to rearrangements through non-allelic homologous recombination, a common source of genomic instability and human disease. Programmed breaks are an essential event in meiosis, however. Vader et al. have identified two proteins, Pch2 and Orc1, that protect the repetitive rDNA array from inappropriate breakages. Surprisingly, Sir2, which establishes the protective heterochromatin environment at rDNA, also makes the border between this heterochromatin and the neighbouring euchromatin susceptible to breaks. Such junctions are therefore at high risk for non-allelic homologous recombination in meiosis.

Suggested Citation

  • Gerben Vader & Hannah G. Blitzblau & Mihoko A. Tame & Jill E. Falk & Lisa Curtin & Andreas Hochwagen, 2011. "Protection of repetitive DNA borders from self-induced meiotic instability," Nature, Nature, vol. 477(7362), pages 115-119, September.
    • Handle: RePEc:nat:nature:v:477:y:2011:i:7362:d:10.1038_nature10331
    DOI: 10.1038/nature10331
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10331
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10331?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:477:y:2011:i:7362:d:10.1038_nature10331. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.