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A two-step chemical mechanism for ribosome-catalysed peptide bond formation

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  • David A. Hiller

    (Yale University)

  • Vipender Singh

    (Yale University
    Present addresses: Department of Chemistry and Bioengineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA (V.S.); AMRI, 30 Corporate Circle, Albany, New York 12203, USA (M.Z.).)

  • Minghong Zhong

    (Yale University
    Present addresses: Department of Chemistry and Bioengineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA (V.S.); AMRI, 30 Corporate Circle, Albany, New York 12203, USA (M.Z.).)

  • Scott A. Strobel

    (Yale University)

Abstract

Catalytic activity of ribosomes The catalytic centre of the ribosome is composed solely of RNA. This means that it lacks the varied side groups found in proteins that can assist in catalysis, so it was thought that its functions were merely to bring messenger RNA and charged transfer RNAs into close proximity. Not so. Analysis of the kinetic isotope effect at five positions within the reaction centre of a peptidyl-transfer RNA mimic shows that the ribosome also enhances catalysis of peptide-bond formation by modifying the rate-limiting transition state. This finding has implications for work on the origin of life and the transition from an RNA world.

Suggested Citation

  • David A. Hiller & Vipender Singh & Minghong Zhong & Scott A. Strobel, 2011. "A two-step chemical mechanism for ribosome-catalysed peptide bond formation," Nature, Nature, vol. 476(7359), pages 236-239, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7359:d:10.1038_nature10248
    DOI: 10.1038/nature10248
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