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HIV-1 adaptation to NK-cell-mediated immune pressure

Author

Listed:
  • Galit Alter

    (Ragon Institute at MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School)

  • David Heckerman

    (Microsoft Research)

  • Arne Schneidewind

    (Ragon Institute at MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School)

  • Lena Fadda

    (Ragon Institute at MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School)

  • Carl M. Kadie

    (Microsoft Research)

  • Jonathan M. Carlson

    (Microsoft Research)

  • Cesar Oniangue-Ndza

    (Ragon Institute at MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School)

  • Maureen Martin

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick Inc., NCI-Frederick, Frederick, Maryland 21702, USA)

  • Bin Li

    (Ragon Institute at MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School)

  • Salim I. Khakoo

    (Imperial College London, London W2 1PG, UK)

  • Mary Carrington

    (Ragon Institute at MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School
    Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC Frederick Inc., NCI-Frederick, Frederick, Maryland 21702, USA)

  • Todd M. Allen

    (Ragon Institute at MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School)

  • Marcus Altfeld

    (Ragon Institute at MGH, MIT and Harvard, Massachusetts General Hospital, Harvard Medical School)

Abstract

Natural killer cells and the control of HIV-1 Recent work has suggested that natural killer (NK) cells contribute to the control of HIV-1 infection through recognition of virally infected cells by both activating and inhibitory killer immunoglobulin-like receptors (KIRs). Alter et al. present evidence that NK cells select HIV escape mutants by an as-yet-undefined mechanism. This results in the inhibition of NK cell function, enabling HIV-1 to escape the potential protective role of this inhibitory KIR.

Suggested Citation

  • Galit Alter & David Heckerman & Arne Schneidewind & Lena Fadda & Carl M. Kadie & Jonathan M. Carlson & Cesar Oniangue-Ndza & Maureen Martin & Bin Li & Salim I. Khakoo & Mary Carrington & Todd M. Allen, 2011. "HIV-1 adaptation to NK-cell-mediated immune pressure," Nature, Nature, vol. 476(7358), pages 96-100, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7358:d:10.1038_nature10237
    DOI: 10.1038/nature10237
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