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Oxysterols direct B-cell migration through EBI2

Author

Listed:
  • Changlu Liu

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

  • Xia V. Yang

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

  • Jiejun Wu

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

  • Chester Kuei

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

  • Neelakandha S. Mani

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

  • Li Zhang

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

  • Jingxue Yu

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

  • Steven W. Sutton

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

  • Ning Qin

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
    Present addresses: Roche R&D Center (China) Ltd., 720 Cai Lun Road, Building 5, Zhangjiang High-Tech Park, Pudong, Shanghai 201203, China (N.Q.); Regulus Therapeutics, 3545 John Hopkins Court, San Diego, California 92121, USA (L.K.).)

  • Homayon Banie

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

  • Lars Karlsson

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
    Present addresses: Roche R&D Center (China) Ltd., 720 Cai Lun Road, Building 5, Zhangjiang High-Tech Park, Pudong, Shanghai 201203, China (N.Q.); Regulus Therapeutics, 3545 John Hopkins Court, San Diego, California 92121, USA (L.K.).)

  • Siquan Sun

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

  • Timothy W. Lovenberg

    (Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row)

Abstract

EBI2 receptors revealed as oxysterols The EBI2 receptor (Epstein–Barr virus-induced gene 2, also known as GPR183) was recently shown to be linked to autoimmune disease, and is a critical regulator of the humoral immune response. It is a G-protein-coupled receptor, and its natural ligand has been unknown. Two groups now bring an end to the 'orphan' status of this receptor with identification of specific oxysterols as its natural ligands. The most potent ligand and activator is 7a,25-dihydroxycholesterol, and the EBI2–oxysterol signalling pathway has an important role in the adaptive immune response.

Suggested Citation

  • Changlu Liu & Xia V. Yang & Jiejun Wu & Chester Kuei & Neelakandha S. Mani & Li Zhang & Jingxue Yu & Steven W. Sutton & Ning Qin & Homayon Banie & Lars Karlsson & Siquan Sun & Timothy W. Lovenberg, 2011. "Oxysterols direct B-cell migration through EBI2," Nature, Nature, vol. 475(7357), pages 519-523, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7357:d:10.1038_nature10226
    DOI: 10.1038/nature10226
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