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Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

Author

Listed:
  • Robert M. Anthony

    (Laboratory of Molecular Genetics and Immunology, The Rockefeller University)

  • Toshihiko Kobayashi

    (Laboratory of Molecular Genetics and Immunology, The Rockefeller University)

  • Fredrik Wermeling

    (Laboratory of Molecular Genetics and Immunology, The Rockefeller University)

  • Jeffrey V. Ravetch

    (Laboratory of Molecular Genetics and Immunology, The Rockefeller University)

Abstract

Anti-inflammatory action by DC-SIGN High-dose intravenous immunoglobulin is used to suppress autoantibody-mediated inflammation in various clinical settings. A study in 'humanized' mice shows that the lectin receptor DC-SIGN initiates this response through an anti-inflammatory cascade induced by a natural ligand — sialylated IgG crystallized fragment — the levels of which are regulated by inflammation. This pathway induces the production of the TH2 cytokines interleukin-33 and interleukin-4 and is a possible therapeutic target for autoimmune diseases.

Suggested Citation

  • Robert M. Anthony & Toshihiko Kobayashi & Fredrik Wermeling & Jeffrey V. Ravetch, 2011. "Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway," Nature, Nature, vol. 475(7354), pages 110-113, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7354:d:10.1038_nature10134
    DOI: 10.1038/nature10134
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