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De novo cardiomyocytes from within the activated adult heart after injury

Author

Listed:
  • Nicola Smart

    (Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK)

  • Sveva Bollini

    (Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK)

  • Karina N. Dubé

    (Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK)

  • Joaquim M. Vieira

    (Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK)

  • Bin Zhou

    (Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences)

  • Sean Davidson

    (The Hatter Cardiovascular Institute, University College London, London WC1E 6HX, USA)

  • Derek Yellon

    (The Hatter Cardiovascular Institute, University College London, London WC1E 6HX, USA)

  • Johannes Riegler

    (Centre for Advanced Biomedical Imaging (CABI), University College London, London WC1E 6DD, UK
    Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London WC1E 6BT, UK)

  • Anthony N. Price

    (MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London W12 0NN, UK)

  • Mark F. Lythgoe

    (Centre for Advanced Biomedical Imaging (CABI), University College London, London WC1E 6DD, UK)

  • William T. Pu

    (Children’s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Paul R. Riley

    (Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK)

Abstract

Repairs of the heart The prospect of cell-based therapy in cardiovascular regenerative medicine comes a step closer with the demonstration that a peptide can stimulate a progenitor cell population in the adult heart to act as a source of new cardiomyocytes. The stem or progenitor cells, thought to be derived from the epicardium, are activated by the small actin monomer binding protein thymosin β4, which has previously been shown to restore vascular potential to adult epicardium-derived progenitor cells after injury. The discovery of a resident source of myocardial progenitors will stimulate a search for small molecules and other factors that promote optimal progenitor activation and replacement of destroyed myocardium.

Suggested Citation

  • Nicola Smart & Sveva Bollini & Karina N. Dubé & Joaquim M. Vieira & Bin Zhou & Sean Davidson & Derek Yellon & Johannes Riegler & Anthony N. Price & Mark F. Lythgoe & William T. Pu & Paul R. Riley, 2011. "De novo cardiomyocytes from within the activated adult heart after injury," Nature, Nature, vol. 474(7353), pages 640-644, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7353:d:10.1038_nature10188
    DOI: 10.1038/nature10188
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