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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

Author

Listed:
  • Nadine Laguette

    (Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France)

  • Bijan Sobhian

    (Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France)

  • Nicoletta Casartelli

    (Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France)

  • Mathieu Ringeard

    (Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France)

  • Christine Chable-Bessia

    (Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France)

  • Emmanuel Ségéral

    (Institut Cochin, Université Paris Descartes, CNRS UMR 8104 INSERM U567, Paris, France)

  • Ahmad Yatim

    (Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France)

  • Stéphane Emiliani

    (Institut Cochin, Université Paris Descartes, CNRS UMR 8104 INSERM U567, Paris, France)

  • Olivier Schwartz

    (Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France)

  • Monsef Benkirane

    (Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France)

Abstract

How macrophages avoid HIV-1 infection HIV-1 is unable to replicate efficiently in dendritic cells, the antigen-presenting tissue cells that function in both innate and adaptive immunity. Other primate lentiviruses, including HIV-2 and some simian immunodeficiency viruses, express a protein called Vpx that is able to overcome the block to replication. Two groups now report the identification of the restriction factor in dendritic cells and macrophages that is overcome by Vpx. Vpx is found to induce degradation of the protein SAMHD1. Mutations in SAMHD1 cause Aicardi–Goutières syndrome, a disorder characterized by inappropriate activation of the immune system. Knockdown of SAMHD1 increases HIV-1 replication in dendritic cells, which could be important for generating appropriate immune responses to the virus.

Suggested Citation

  • Nadine Laguette & Bijan Sobhian & Nicoletta Casartelli & Mathieu Ringeard & Christine Chable-Bessia & Emmanuel Ségéral & Ahmad Yatim & Stéphane Emiliani & Olivier Schwartz & Monsef Benkirane, 2011. "SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx," Nature, Nature, vol. 474(7353), pages 654-657, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7353:d:10.1038_nature10117
    DOI: 10.1038/nature10117
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