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MicroRNAs 103 and 107 regulate insulin sensitivity

Author

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  • Mirko Trajkovski

    (Institute for Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli Strasse 16, CH-8093 Zurich, Switzerland
    Competence Center of Systems Physiology and Metabolic Disease, ETH Zurich, Schafmattstrasse 18, HPM F 39.1 CH-8093 Zurich, Switzerland)

  • Jean Hausser

    (Competence Center of Systems Physiology and Metabolic Disease, ETH Zurich, Schafmattstrasse 18, HPM F 39.1 CH-8093 Zurich, Switzerland
    Biozentrum Basel, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland)

  • Jürgen Soutschek

    (Regulus Therapeutics Inc., 3545 John Hopkins Court)

  • Bal Bhat

    (Regulus Therapeutics Inc., 3545 John Hopkins Court)

  • Akinc Akin

    (Alnylam Pharmaceuticals, 300 Third Street)

  • Mihaela Zavolan

    (Biozentrum Basel, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland)

  • Markus H. Heim

    (Competence Center of Systems Physiology and Metabolic Disease, ETH Zurich, Schafmattstrasse 18, HPM F 39.1 CH-8093 Zurich, Switzerland
    University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland)

  • Markus Stoffel

    (Institute for Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli Strasse 16, CH-8093 Zurich, Switzerland
    Competence Center of Systems Physiology and Metabolic Disease, ETH Zurich, Schafmattstrasse 18, HPM F 39.1 CH-8093 Zurich, Switzerland)

Abstract

A new target for diabetes and obesity drugs A microRNA (miRNA) microarray analysis of the livers of two mouse models of obesity show that the expression of miRNA-103 and miRNA-107 is upregulated in obesity. Silencing these miRNAs improves glucose homeostasis and insulin sensitivity. Turning them on in liver or fat is sufficient to impair glucose homeostasis. Caveolin-1, a protein involved in regulation of insulin signalling, is a direct target gene of the miRNAs. These findings show that these miRNAs regulate insulin sensitivity and identify a new potential target for the treatment of type 2 diabetes and obesity.

Suggested Citation

  • Mirko Trajkovski & Jean Hausser & Jürgen Soutschek & Bal Bhat & Akinc Akin & Mihaela Zavolan & Markus H. Heim & Markus Stoffel, 2011. "MicroRNAs 103 and 107 regulate insulin sensitivity," Nature, Nature, vol. 474(7353), pages 649-653, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7353:d:10.1038_nature10112
    DOI: 10.1038/nature10112
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