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Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

Author

Listed:
  • Leif E. Sander

    (Immunology Institute, Mount Sinai School of Medicine)

  • Michael J. Davis

    (University of Michigan)

  • Mark V. Boekschoten

    (Nutrition, Metabolism and Genomics Group, Wageningen University)

  • Derk Amsen

    (Academic Medical Center, University of Amsterdam)

  • Christopher C. Dascher

    (Immunology Institute, Mount Sinai School of Medicine)

  • Bernard Ryffel

    (Laboratory of Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique)

  • Joel A. Swanson

    (University of Michigan)

  • Michael Müller

    (Nutrition, Metabolism and Genomics Group, Wageningen University)

  • J. Magarian Blander

    (Immunology Institute, Mount Sinai School of Medicine)

Abstract

Where there's life there's a PAMP The innate immune system targets PAMPs (pathogen-associated molecular patterns) — invariant molecules crucial to the composition of microbial cells but absent from host tissues — to discriminate self from non-self structures. Now, a similar mechanism has been implicated in determining the differences in the immune response to viable and dead pathogens. Sander et al. identify stimulatory messenger RNA, present in live but not dead bacteria, as a viability-associated PAMP, or vita-PAMP. By incorporating vita-PAMPs in vaccines, it might be possible to combine the efficacy of a live vaccine with the safety associated with dead vaccines.

Suggested Citation

  • Leif E. Sander & Michael J. Davis & Mark V. Boekschoten & Derk Amsen & Christopher C. Dascher & Bernard Ryffel & Joel A. Swanson & Michael Müller & J. Magarian Blander, 2011. "Detection of prokaryotic mRNA signifies microbial viability and promotes immunity," Nature, Nature, vol. 474(7351), pages 385-389, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7351:d:10.1038_nature10072
    DOI: 10.1038/nature10072
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