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Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1

Author

Listed:
  • Momoko Maekawa

    (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
    Yamanaka iPS Cell Special Project, JST, Kawaguchi 332-0012, Japan)

  • Kei Yamaguchi

    (Japan Biological Informatics Consortium, Tokyo 135-0064, Japan)

  • Tomonori Nakamura

    (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
    Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8507, Japan)

  • Ran Shibukawa

    (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
    Yamanaka iPS Cell Special Project, JST, Kawaguchi 332-0012, Japan)

  • Ikumi Kodanaka

    (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
    Yamanaka iPS Cell Special Project, JST, Kawaguchi 332-0012, Japan)

  • Tomoko Ichisaka

    (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
    Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8507, Japan)

  • Yoshifumi Kawamura

    (Japan Biological Informatics Consortium, Tokyo 135-0064, Japan)

  • Hiromi Mochizuki

    (Japan Biological Informatics Consortium, Tokyo 135-0064, Japan)

  • Naoki Goshima

    (Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan)

  • Shinya Yamanaka

    (Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
    Yamanaka iPS Cell Special Project, JST, Kawaguchi 332-0012, Japan
    Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8507, Japan
    Gladstone Institute of Cardiovascular Disease)

Abstract

Glis1 substitutes for c-Myc in stem-cell generation Reprogramming of differentiated somatic cells to induced pluripotent stem (iPS) cells by exogenous expression of key transcription factors (Oct4, Sox2, Klf4 and c-Myc) has potential therapeutic applications. c-Myc enhances the efficiency of reprogramming, but the safety of using this oncogene has long been a concern. Now, Shinya Yamanaka and colleagues have found that the transcription factor Glis1 effectively and specifically promotes reprogramming of human and mouse somatic cells to iPS cells. Glis1 is highly enriched in unfertilized eggs and one-cell-stage embryos, and might be a link between reprogramming during iPS cell generation and after nuclear transfer into zygotes.

Suggested Citation

  • Momoko Maekawa & Kei Yamaguchi & Tomonori Nakamura & Ran Shibukawa & Ikumi Kodanaka & Tomoko Ichisaka & Yoshifumi Kawamura & Hiromi Mochizuki & Naoki Goshima & Shinya Yamanaka, 2011. "Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1," Nature, Nature, vol. 474(7350), pages 225-229, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7350:d:10.1038_nature10106
    DOI: 10.1038/nature10106
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