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Glutamate induces de novo growth of functional spines in developing cortex

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  • Hyung-Bae Kwon

    (Howard Hughes Medical Institute, Harvard Medical School)

  • Bernardo L. Sabatini

    (Howard Hughes Medical Institute, Harvard Medical School)

Abstract

Early neural development It is known that dendritic spines are formed de novo in the developing brain in response to learning and sensory experiences, but the biochemistry underlying this process remains unknown. Hyung-Bae Kwon and Bernardo Sabatini combine single-spine imaging and light-controlled neurotransmitter release (uncaging) to demonstrate new spine growth in response to glutamate at specific locations along a dendrite. The process requires functional NMDA receptors and PKA signalling, with new spines rapidly maturing and responding to presynaptic signals. These data suggest that neural activity can rapidly initiate new connections in a location-specific manner along dendrites.

Suggested Citation

  • Hyung-Bae Kwon & Bernardo L. Sabatini, 2011. "Glutamate induces de novo growth of functional spines in developing cortex," Nature, Nature, vol. 474(7349), pages 100-104, June.
    • Handle: RePEc:nat:nature:v:474:y:2011:i:7349:d:10.1038_nature09986
    DOI: 10.1038/nature09986
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    Cited by:

    1. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "The Formation of Multi-synaptic Connections by the Interaction of Synaptic and Structural Plasticity and Their Functional Consequences," PLOS Computational Biology, Public Library of Science, vol. 11(1), pages 1-29, January.
    2. Scott R. Burlingham & Nicole F. Wong & Lindsay Peterkin & Lily Lubow & Carolina Dos Santos Passos & Orion Benner & Michael Ghebrial & Thomas P. Cast & Matthew A. Xu-Friedman & Thomas C. Südhof & Soham, 2022. "Induction of synapse formation by de novo neurotransmitter synthesis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Yixin Wu & Mingzheng Wu & Abraham Vázquez-Guardado & Joohee Kim & Xin Zhang & Raudel Avila & Jin-Tae Kim & Yujun Deng & Yongjoon Yu & Sarah Melzer & Yun Bai & Hyoseo Yoon & Lingzi Meng & Yi Zhang & He, 2022. "Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Michael Fauth & Florentin Wörgötter & Christian Tetzlaff, 2015. "Formation and Maintenance of Robust Long-Term Information Storage in the Presence of Synaptic Turnover," PLOS Computational Biology, Public Library of Science, vol. 11(12), pages 1-22, December.

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