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Heart regeneration

Author

Listed:
  • Michael A. Laflamme

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington)

  • Charles E. Murry

    (Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington
    Deparment of Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington
    Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington)

Abstract

Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate lost myocardium could help millions of patients every year. Heart regeneration is well documented in amphibia and fish and in developing mammals. After birth, however, human heart regeneration becomes limited to very slow cardiomyocyte replacement. Several experimental strategies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in progress. Although many challenges remain, these interventions may eventually lead to better approaches to treat or prevent heart failure.

Suggested Citation

  • Michael A. Laflamme & Charles E. Murry, 2011. "Heart regeneration," Nature, Nature, vol. 473(7347), pages 326-335, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7347:d:10.1038_nature10147
    DOI: 10.1038/nature10147
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