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Stem-cell-triggered immunity through CLV3p–FLS2 signalling

Author

Listed:
  • Horim Lee

    (Massachusetts General Hospital, Harvard Medical School)

  • Ok-Kyong Chah

    (Massachusetts General Hospital, Harvard Medical School)

  • Jen Sheen

    (Massachusetts General Hospital, Harvard Medical School)

Abstract

Development and immunity linked The plant stem cells in the shoot apical meristem provide a self-renewable reservoir for leaf, stem and flower organogenesis and are generally protected against stresses and disease. The molecular basis of this immunity has now been discovered. The CLV3 peptide (CLV3p) signal — which is secreted by stem cells in the Arabidopsis shoot apical meristem and which normally controls stem-cell homeostasis through CLV1 and CLV2 receptors — also triggers innate immune signalling through the bacterial flagellin peptide receptor kinase FLS2. The CLV3p–FLS2 signalling acts independently from the stem-cell signalling pathway. These findings suggest co-evolution in peptide–receptor signalling for development and immunity.

Suggested Citation

  • Horim Lee & Ok-Kyong Chah & Jen Sheen, 2011. "Stem-cell-triggered immunity through CLV3p–FLS2 signalling," Nature, Nature, vol. 473(7347), pages 376-379, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7347:d:10.1038_nature09958
    DOI: 10.1038/nature09958
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