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Neuropsin cleaves EphB2 in the amygdala to control anxiety

Author

Listed:
  • Benjamin K. Attwood

    (University of Leicester, University Road)

  • Julie-Myrtille Bourgognon

    (University of Leicester, University Road)

  • Satyam Patel

    (University of Leicester, University Road)

  • Mariusz Mucha

    (University of Leicester, University Road)

  • Emanuele Schiavon

    (University of Leicester, University Road)

  • Anna E. Skrzypiec

    (University of Leicester, University Road)

  • Kenneth W. Young

    (Medical Research Council Toxicology Unit, Lancaster Road)

  • Sadao Shiosaka

    (Nara Institute of Science and Technology)

  • Michal Korostynski

    (Institute of Pharmacology)

  • Marcin Piechota

    (Institute of Pharmacology)

  • Ryszard Przewlocki

    (Institute of Pharmacology)

  • Robert Pawlak

    (University of Leicester, University Road)

Abstract

Cause for anxiety Many individuals experience traumatic events, but some people seem relatively unaffected whereas others develop post-traumatic stress disorder. Now, work in mice has identified a possible cause for this variation between individuals. During stress, the serine protease neuropsin elicits plasticity in the amygdala by regulating EphB2/NMDA receptor interactions, inducing expression of the fear-related gene Fkbp5v. Mice lacking neuropsin do not exhibit the same dynamic plasticity in response to stress. These results underscore the importance of molecular pathways in the manifestation of complex behaviours such as anxiety, and point to Eph and NMDA receptors as possible therapeutic targets.

Suggested Citation

  • Benjamin K. Attwood & Julie-Myrtille Bourgognon & Satyam Patel & Mariusz Mucha & Emanuele Schiavon & Anna E. Skrzypiec & Kenneth W. Young & Sadao Shiosaka & Michal Korostynski & Marcin Piechota & Rysz, 2011. "Neuropsin cleaves EphB2 in the amygdala to control anxiety," Nature, Nature, vol. 473(7347), pages 372-375, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7347:d:10.1038_nature09938
    DOI: 10.1038/nature09938
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