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Modelling schizophrenia using human induced pluripotent stem cells

Author

Listed:
  • Kristen J. Brennand

    (Salk Institute for Biological Studies, Laboratory of Genetics)

  • Anthony Simone

    (Salk Institute for Biological Studies, Laboratory of Genetics)

  • Jessica Jou

    (Salk Institute for Biological Studies, Laboratory of Genetics)

  • Chelsea Gelboin-Burkhart

    (Salk Institute for Biological Studies, Laboratory of Genetics)

  • Ngoc Tran

    (Salk Institute for Biological Studies, Laboratory of Genetics)

  • Sarah Sangar

    (Salk Institute for Biological Studies, Laboratory of Genetics)

  • Yan Li

    (Salk Institute for Biological Studies, Laboratory of Genetics)

  • Yangling Mu

    (Salk Institute for Biological Studies, Laboratory of Genetics)

  • Gong Chen

    (Pennsylvania State University, 201 Life Science Building, University Park)

  • Diana Yu

    (Salk Institute for Biological Studies, Laboratory of Genetics)

  • Shane McCarthy

    (Cold Spring Harbor Laboratory, 1 Bungtown Road)

  • Jonathan Sebat

    (University of California San Diego, University Of California)

  • Fred H. Gage

    (Salk Institute for Biological Studies, Laboratory of Genetics)

Abstract

A model for schizophrenia Many cellular and molecular phenomena have been described in neurons of schizophrenic patients, mostly based on post-mortem data, but there is still no clear understanding of mechanisms underlying the disease. Gage and colleagues now demonstrate the feasibility of generating a human cell-based model of schizophrenia. Fibroblasts from patients with schizophrenia were reprogrammed into induced pluripotent stem cells and subsequently differentiated into neurons. These neurons displayed a number of schizophrenia-associated phenotypes, including reduced connectivity and altered gene expression, some of which could be rescued by an antipsychotic.

Suggested Citation

  • Kristen J. Brennand & Anthony Simone & Jessica Jou & Chelsea Gelboin-Burkhart & Ngoc Tran & Sarah Sangar & Yan Li & Yangling Mu & Gong Chen & Diana Yu & Shane McCarthy & Jonathan Sebat & Fred H. Gage, 2011. "Modelling schizophrenia using human induced pluripotent stem cells," Nature, Nature, vol. 473(7346), pages 221-225, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7346:d:10.1038_nature09915
    DOI: 10.1038/nature09915
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    Cited by:

    1. Lorna A. Farrelly & Shuangping Zheng & Nadine Schrode & Aaron Topol & Natarajan V. Bhanu & Ryan M. Bastle & Aarthi Ramakrishnan & Jennifer C Chan & Bulent Cetin & Erin Flaherty & Li Shen & Kelly Gleas, 2022. "Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Sasha L. Fulton & Wendy Wenderski & Ashley E. Lepack & Andrew L. Eagle & Tomas Fanutza & Ryan M. Bastle & Aarthi Ramakrishnan & Emma C. Hays & Arianna Neal & Jaroslav Bendl & Lorna A. Farrelly & Amni , 2022. "Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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