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Differential microRNA regulation of HLA-C expression and its association with HIV control

Author

Listed:
  • Smita Kulkarni

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University)

  • Ram Savan

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, NCI-Frederick)

  • Ying Qi

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University)

  • Xiaojiang Gao

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University)

  • Yuko Yuki

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University)

  • Sara E. Bass

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick)

  • Maureen P. Martin

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University)

  • Peter Hunt

    (University of California)

  • Steven G. Deeks

    (University of California)

  • Amalio Telenti

    (Institute of Microbiology, University of Lausanne)

  • Florencia Pereyra

    (Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University)

  • David Goldstein

    (Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University)

  • Steven Wolinsky

    (The Feinberg School of Medicine, Northwestern University)

  • Bruce Walker

    (Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University)

  • Howard A. Young

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, NCI-Frederick)

  • Mary Carrington

    (Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick
    Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University)

Abstract

An HLA class I gene regulated by microRNA Variation in cell-surface levels and expression of the major histocompatibility complex component HLA-C have been implicated in the control of HIV viral load and progression to AIDS. The microRNA miR-148a is now shown to regulate the expression of HLA-C expression and its effects on HIV. The discovery of a role for a microRNA in this process raises the possibility of new approaches to immunotherapy.

Suggested Citation

  • Smita Kulkarni & Ram Savan & Ying Qi & Xiaojiang Gao & Yuko Yuki & Sara E. Bass & Maureen P. Martin & Peter Hunt & Steven G. Deeks & Amalio Telenti & Florencia Pereyra & David Goldstein & Steven Wolin, 2011. "Differential microRNA regulation of HLA-C expression and its association with HIV control," Nature, Nature, vol. 472(7344), pages 495-498, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7344:d:10.1038_nature09914
    DOI: 10.1038/nature09914
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