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Distinct representations of olfactory information in different cortical centres

Author

Listed:
  • Dara L. Sosulski

    (College of Physicians and Surgeons, Columbia University)

  • Maria Lissitsyna Bloom

    (College of Physicians and Surgeons, Columbia University
    Present addresses: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (M.L.B., S.R.D.); Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA (T.C.).)

  • Tyler Cutforth

    (College of Physicians and Surgeons, Columbia University
    Present addresses: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (M.L.B., S.R.D.); Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA (T.C.).)

  • Richard Axel

    (College of Physicians and Surgeons, Columbia University)

  • Sandeep Robert Datta

    (College of Physicians and Surgeons, Columbia University
    Present addresses: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (M.L.B., S.R.D.); Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA (T.C.).)

Abstract

Scent tracking In the mouse, glomeruli in the olfactory bulb receive projections from single classes of olfactory neurons, thereby forming an odour map. Information from the glomeruli is then relayed to the cortex but the projection patterns from individual glomeruli are not known. Three papers now examine the details of this projection. Luo and colleagues use a combination of genetics and retrograde mono-trans-synaptic rabies virus labelling. They trace the presynaptic connections of individual cortical neurons and find no evidence of connections supporting a stereotyped odour map in the cortex, but see systematic topographical differences in amygdala connectivity. The lack of stereotypical cortical projection is corroborated, both at the level of bulk axonal patterning and in projections of individually labelled neurons, by two papers — one from the Axel laboratory, and one from the Baldwin laboratory — that examine the anterograde projections from individual glomeruli. Together, these findings provide anatomical evidence for combinatorial processing of information from diverse glomeruli by cortical neurons and may also reflect different functions of various areas in mediating innate or learned odour preferences.

Suggested Citation

  • Dara L. Sosulski & Maria Lissitsyna Bloom & Tyler Cutforth & Richard Axel & Sandeep Robert Datta, 2011. "Distinct representations of olfactory information in different cortical centres," Nature, Nature, vol. 472(7342), pages 213-216, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7342:d:10.1038_nature09868
    DOI: 10.1038/nature09868
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    Cited by:

    1. Gaia Tavoni & David E Chen Kersen & Vijay Balasubramanian, 2021. "Cortical feedback and gating in odor discrimination and generalization," PLOS Computational Biology, Public Library of Science, vol. 17(10), pages 1-35, October.
    2. Geoffrey Terral & Evan Harrell & Gabriel Lepousez & Yohan Wards & Dinghuang Huang & Tiphaine Dolique & Giulio Casali & Antoine Nissant & Pierre-Marie Lledo & Guillaume Ferreira & Giovanni Marsicano & , 2024. "Endogenous cannabinoids in the piriform cortex tune olfactory perception," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Joseph D. Zak & Gautam Reddy & Vaibhav Konanur & Venkatesh N. Murthy, 2024. "Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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