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Dampening of death pathways by schnurri-2 is essential for T-cell development

Author

Listed:
  • Tracy L. Staton

    (Harvard School of Public Health)

  • Vanja Lazarevic

    (Harvard School of Public Health)

  • Dallas C. Jones

    (Harvard School of Public Health)

  • Amanda J. Lanser

    (Harvard School of Public Health)

  • Tsuyoshi Takagi

    (Laboratory of Molecular Genetics, RIKEN Tsukuba Institute)

  • Shunsuke Ishii

    (Laboratory of Molecular Genetics, RIKEN Tsukuba Institute)

  • Laurie H. Glimcher

    (Harvard School of Public Health
    Harvard Medical School
    The Ragon Institute of MGH/MIT and Harvard)

Abstract

The path to T cells not dead cells Considerable study has focused on how thymocytes — progenitors in the thymus that produce T lymphocytes — distinguish between signal intensities leading to the opposing fates of differentiation and death. However, the mechanisms that maintain these boundaries remain unknown. The zinc-finger-containing protein schnurri-2 is now shown to regulate positive selection in T-cell development by dampening the mitochondrial death pathway.

Suggested Citation

  • Tracy L. Staton & Vanja Lazarevic & Dallas C. Jones & Amanda J. Lanser & Tsuyoshi Takagi & Shunsuke Ishii & Laurie H. Glimcher, 2011. "Dampening of death pathways by schnurri-2 is essential for T-cell development," Nature, Nature, vol. 472(7341), pages 105-109, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7341:d:10.1038_nature09848
    DOI: 10.1038/nature09848
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