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A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

Author

Listed:
  • Kevin C. Wang

    (Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine
    University of California San Francisco (UCSF))

  • Yul W. Yang

    (Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine)

  • Bo Liu

    (Stanford University School of Medicine)

  • Amartya Sanyal

    (Program in Gene Function and Expression, Dept. of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School)

  • Ryan Corces-Zimmerman

    (Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine)

  • Yong Chen

    (Howard Hughes Medical Institute, University of Michigan Medical School)

  • Bryan R. Lajoie

    (Program in Gene Function and Expression, Dept. of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School)

  • Angeline Protacio

    (Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine)

  • Ryan A. Flynn

    (Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine)

  • Rajnish A. Gupta

    (Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine)

  • Joanna Wysocka

    (Stanford University School of Medicine)

  • Ming Lei

    (Howard Hughes Medical Institute, University of Michigan Medical School)

  • Job Dekker

    (Program in Gene Function and Expression, Dept. of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School)

  • Jill A. Helms

    (Stanford University School of Medicine)

  • Howard Y. Chang

    (Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine)

Abstract

Long-range genetic regulation A major question in developmental biology is how functionally related groups of genes are switched on at the right time and in the right place. Long intergenic non-coding RNAs (lincRNAs) have been implicated in both gene silencing and activation, and could be a means of long-range control of gene expression. A lincRNA termed HOTTIP that coordinates the activation of multiple 5' HOXA regulatory genes has now been identified at the 5' tip of the HOXA locus. Chromosomal looping brings HOTTIP close its target genes, where it facilitates histone H3 lysine 4 trimethylation and gene transcription.

Suggested Citation

  • Kevin C. Wang & Yul W. Yang & Bo Liu & Amartya Sanyal & Ryan Corces-Zimmerman & Yong Chen & Bryan R. Lajoie & Angeline Protacio & Ryan A. Flynn & Rajnish A. Gupta & Joanna Wysocka & Ming Lei & Job Dek, 2011. "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression," Nature, Nature, vol. 472(7341), pages 120-124, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7341:d:10.1038_nature09819
    DOI: 10.1038/nature09819
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