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Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

Author

Listed:
  • Vladimir Vacic

    (Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory
    Columbia University)

  • Shane McCarthy

    (Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory)

  • Dheeraj Malhotra

    (Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory
    Beyster Center for Genomics of Psychiatric Diseases, University of California
    University of California)

  • Fiona Murray

    (University of California
    University of California)

  • Hsun-Hua Chou

    (Beyster Center for Genomics of Psychiatric Diseases, University of California
    University of California)

  • Aine Peoples

    (Neuropsychiatric Genetics Research Group, Trinity College Dublin)

  • Vladimir Makarov

    (Seaver Autism Center, Mount Sinai School of Medicine
    Mount Sinai School of Medicine)

  • Seungtai Yoon

    (Seaver Autism Center, Mount Sinai School of Medicine
    Mount Sinai School of Medicine)

  • Abhishek Bhandari

    (Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory
    Beyster Center for Genomics of Psychiatric Diseases, University of California
    University of California)

  • Roser Corominas

    (University of California)

  • Lilia M. Iakoucheva

    (University of California)

  • Olga Krastoshevsky

    (McLean Hospital)

  • Verena Krause

    (McLean Hospital)

  • Verónica Larach-Walters

    (Faculty of Medicine, Universidad Andrés Bello)

  • David K. Welsh

    (University of California
    Veterans Affairs San Diego Healthcare System
    Center for Chronobiology, University of California)

  • David Craig

    (Translational Genomics Research Institute)

  • John R. Kelsoe

    (University of California
    Veterans Affairs San Diego Healthcare System
    Institute for Genomic Medicine, University of California)

  • Elliot S. Gershon

    (The University of Chicago)

  • Suzanne M. Leal

    (Baylor College of Medicine)

  • Marie Dell Aquila

    (University of California
    University of California)

  • Derek W. Morris

    (Neuropsychiatric Genetics Research Group, Trinity College Dublin)

  • Michael Gill

    (Neuropsychiatric Genetics Research Group, Trinity College Dublin)

  • Aiden Corvin

    (Neuropsychiatric Genetics Research Group, Trinity College Dublin)

  • Paul A. Insel

    (University of California
    University of California)

  • Jon McClellan

    (University of Washington)

  • Mary-Claire King

    (University of Washington
    University of Washington)

  • Maria Karayiorgou

    (Columbia University)

  • Deborah L. Levy

    (McLean Hospital)

  • Lynn E. DeLisi

    (Boston VA Healthcare System and Harvard Medical School)

  • Jonathan Sebat

    (Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory
    Beyster Center for Genomics of Psychiatric Diseases, University of California
    University of California
    Institute for Genomic Medicine, University of California)

Abstract

VIP2 receptor link to schizophrenia Based on genome-wide analysis of copy number variants in two large schizophrenia cohorts, Vacic et al. report a significant association between duplications within a region of chromosome 7 and schizophrenia. Using microduplication analysis, the region affected was narrowed down to 7q36.3, just upstream of a gene encoding vasoactive intestinal peptide receptor (VIPR2). Increased expression of VIPR2 in patients with schizophrenia implicates VIP signalling as a molecular mechanism underlying schizophrenia. This work points to the VIPR2 receptor as a potential target for antipsychotic drugs.

Suggested Citation

  • Vladimir Vacic & Shane McCarthy & Dheeraj Malhotra & Fiona Murray & Hsun-Hua Chou & Aine Peoples & Vladimir Makarov & Seungtai Yoon & Abhishek Bhandari & Roser Corominas & Lilia M. Iakoucheva & Olga K, 2011. "Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia," Nature, Nature, vol. 471(7339), pages 499-503, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7339:d:10.1038_nature09884
    DOI: 10.1038/nature09884
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