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Chromosome length influences replication-induced topological stress

Author

Listed:
  • Andreas Kegel

    (Karolinska Institutet, von Eulers väg 3)

  • Hanna Betts-Lindroos

    (Karolinska Institutet, von Eulers väg 3)

  • Takaharu Kanno

    (Karolinska Institutet, von Eulers väg 3)

  • Kristian Jeppsson

    (Karolinska Institutet, von Eulers väg 3)

  • Lena Ström

    (Karolinska Institutet, von Eulers väg 3)

  • Yuki Katou

    (Laboratory of In Silico Functional Genomics, Graduate School of Bioscience, Tokyo Institute of Technology, 4259 Nagatsuta)

  • Takehiko Itoh

    (Laboratory of In Silico Functional Genomics, Graduate School of Bioscience, Tokyo Institute of Technology, 4259 Nagatsuta)

  • Katsuhiko Shirahige

    (Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi)

  • Camilla Sjögren

    (Karolinska Institutet, von Eulers väg 3)

Abstract

Stress relief for chromosomes As the replication fork progresses along parental DNA during chromosome replication, there is a build-up of topological stress ahead of the polymerase. Current models propose that linear eukaryotic chromosomes are divided into topological domains, and that stress is relieved by the activity of a topoisomerase. Camilla Sjögren and colleagues find that replication stress is present throughout the chromosome, and that the relief of stress in longer chromosomes is facilitated by the activity of the cohesin/condensin-like Smc5/6 complex as well as by topoisomerase. They propose that the Smc5/6 complex prevent formation of topological tension ahead of the replication fork by promoting fork rotation, leading to the formation of sister chromatin intertwinings behind.

Suggested Citation

  • Andreas Kegel & Hanna Betts-Lindroos & Takaharu Kanno & Kristian Jeppsson & Lena Ström & Yuki Katou & Takehiko Itoh & Katsuhiko Shirahige & Camilla Sjögren, 2011. "Chromosome length influences replication-induced topological stress," Nature, Nature, vol. 471(7338), pages 392-396, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7338:d:10.1038_nature09791
    DOI: 10.1038/nature09791
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