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Co-directional replication–transcription conflicts lead to replication restart

Author

Listed:
  • Houra Merrikh

    (Building 68-530, M.I.T.)

  • Cristina Machón

    (Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park)

  • William H. Grainger

    (Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park)

  • Alan D. Grossman

    (Building 68-530, M.I.T.)

  • Panos Soultanas

    (Centre for Biomolecular Sciences, School of Chemistry, University of Nottingham, University Park)

Abstract

Transcription and replication in conflict As the rates of DNA replication and transcription are different, the machineries that carry out these processes are bound to clash sometimes on the DNA helix. In contrast to results from head-on collisions, co-directional encounters have been shown to have mild effects in vitro, requiring no additional replication restart factors. Alan Grossman, Panos Soultanas and colleagues now show that in bacterial cells, highly transcribed genes are 'hotspots' for conflicts between transcription and replication. Such conflicts cause replication to pause or stall, and both types of events require the activities of restart proteins to resume replication.

Suggested Citation

  • Houra Merrikh & Cristina Machón & William H. Grainger & Alan D. Grossman & Panos Soultanas, 2011. "Co-directional replication–transcription conflicts lead to replication restart," Nature, Nature, vol. 470(7335), pages 554-557, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7335:d:10.1038_nature09758
    DOI: 10.1038/nature09758
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