IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v470y2011i7334d10.1038_nature09703.html
   My bibliography  Save this article

Coronin 2A mediates actin-dependent de-repression of inflammatory response genes

Author

Listed:
  • Wendy Huang

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
    Biomedical Sciences Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Serena Ghisletti

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
    Present address: Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.)

  • Kaoru Saijo

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Meghal Gandhi

    (Rosenstiel Basic Medical Science Research Center, Brandeis University)

  • Myriam Aouadi

    (Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA)

  • Greg J. Tesz

    (Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA)

  • Dawn X. Zhang

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
    Biomedical Sciences Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Joyee Yao

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Michael P. Czech

    (Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA)

  • Bruce L. Goode

    (Rosenstiel Basic Medical Science Research Center, Brandeis University)

  • Michael G. Rosenfeld

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
    Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

  • Christopher K. Glass

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
    University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA)

Abstract

Control of inflammatory responses Activation of inflammatory gene expression by toll-like receptor (TLR) signalling pathways involves the removal of gene repression complexes such as NCoR. Coronin 2A, a component of the NCoR complex, is now shown to mediate TLR-induced NCoR turnover and de-repression of inflammatory genes by a mechanism involving interaction with oligomeric nuclear actin. This work points to a role for an actin-dependent mechanism in the de-repression of TLR target genes that is regulated by phosphorylation and nuclear receptor signalling pathways to differentially control inflammatory responses.

Suggested Citation

  • Wendy Huang & Serena Ghisletti & Kaoru Saijo & Meghal Gandhi & Myriam Aouadi & Greg J. Tesz & Dawn X. Zhang & Joyee Yao & Michael P. Czech & Bruce L. Goode & Michael G. Rosenfeld & Christopher K. Glas, 2011. "Coronin 2A mediates actin-dependent de-repression of inflammatory response genes," Nature, Nature, vol. 470(7334), pages 414-418, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7334:d:10.1038_nature09703
    DOI: 10.1038/nature09703
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09703
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09703?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:470:y:2011:i:7334:d:10.1038_nature09703. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.