IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v470y2011i7334d10.1038_nature09673.html

Some searches may not work properly. We apologize for the inconvenience.

   My bibliography  Save this article

CKIα ablation highlights a critical role for p53 in invasiveness control

Author

Listed:
  • Ela Elyada

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Ariel Pribluda

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Robert E. Goldstein

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Yael Morgenstern

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Guy Brachya

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Gady Cojocaru

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Irit Snir-Alkalay

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Ido Burstain

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Rebecca Haffner-Krausz

    (The Weizmann Institute of Science, Rehovot 76100, Israel)

  • Steffen Jung

    (The Weizmann Institute of Science, Rehovot 76100, Israel)

  • Zoltan Wiener

    (Molecular Cancer Biology Program and the Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki, Helsinki 00014, Finland)

  • Kari Alitalo

    (Molecular Cancer Biology Program and the Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki, Helsinki 00014, Finland)

  • Moshe Oren

    (The Weizmann Institute of Science, Rehovot 76100, Israel)

  • Eli Pikarsky

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel
    IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

  • Yinon Ben-Neriah

    (The Lautenberg Center for Immunology, IMRIC, Hebrew University—Hadassah Medical School, Jerusalem 91120, Israel)

Abstract

The role of p53 in metastasis In a mouse model of intestinal cancer, Yinon Ben-Neriah and colleagues show that in the absence of CK1-α, the loss of p53 dramatically enhances tumour progression and metastasis. The tumour repressor p53 normally limits cancer cell invasion through the regulation of p21 and a set of invasion genes that include Prox1. This study adds more detail to the emerging picture that during tumour development, the p53 gene not only controls cell death and proliferation but also metastasis.

Suggested Citation

  • Ela Elyada & Ariel Pribluda & Robert E. Goldstein & Yael Morgenstern & Guy Brachya & Gady Cojocaru & Irit Snir-Alkalay & Ido Burstain & Rebecca Haffner-Krausz & Steffen Jung & Zoltan Wiener & Kari Ali, 2011. "CKIα ablation highlights a critical role for p53 in invasiveness control," Nature, Nature, vol. 470(7334), pages 409-413, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7334:d:10.1038_nature09673
    DOI: 10.1038/nature09673
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09673
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09673?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tingting Niu & Charlotte Rosny & Séverine Chautard & Amaury Rey & Danish Patoli & Marine Groslambert & Camille Cosson & Brice Lagrange & Zhirong Zhang & Orane Visvikis & Sabine Hacot & Maggy Hologne &, 2021. "NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:470:y:2011:i:7334:d:10.1038_nature09673. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.