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Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

Author

Listed:
  • Daniel Cortázar

    (Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland)

  • Christophe Kunz

    (Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland)

  • Jim Selfridge

    (The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK)

  • Teresa Lettieri

    (Institute of Molecular Cancer Research, University of Zürich, 8057 Zürich, Switzerland
    Present addresses: European Commission, Joint Research Centre, Institute for Environment and Sustainability, 21027 Ispra, Italy (T.L.); Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK (R.S.).)

  • Yusuke Saito

    (Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland)

  • Eilidh MacDougall

    (The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK)

  • Annika Wirz

    (Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland)

  • David Schuermann

    (Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland)

  • Angelika L. Jacobs

    (Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland)

  • Fredy Siegrist

    (Pharmaceutical Research, Global Preclinical Safety, F. Hoffmann-La Roche Ltd., 4058 Basel, Switzerland)

  • Roland Steinacher

    (Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland
    Present addresses: European Commission, Joint Research Centre, Institute for Environment and Sustainability, 21027 Ispra, Italy (T.L.); Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK (R.S.).)

  • Josef Jiricny

    (Institute of Molecular Cancer Research, University of Zürich, 8057 Zürich, Switzerland)

  • Adrian Bird

    (The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK)

  • Primo Schär

    (Institute of Biochemistry and Genetics, University of Basel, 4048 Basel, Switzerland)

Abstract

DNA repair role in cell differentiation The DNA repair enzyme thymine DNA glycolase (TDG) has been implicated in gene regulation, but its biological functions are unclear. Tdg gene knockouts in mice now reveal that the enzyme is essential for embryonic development, acting to maintain active and bivalent chromatin states during cell differentiation. TDG-dependent DNA repair may therefore have evolved to maintain epigenetic stability in lineage-committed cells.

Suggested Citation

  • Daniel Cortázar & Christophe Kunz & Jim Selfridge & Teresa Lettieri & Yusuke Saito & Eilidh MacDougall & Annika Wirz & David Schuermann & Angelika L. Jacobs & Fredy Siegrist & Roland Steinacher & Jose, 2011. "Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability," Nature, Nature, vol. 470(7334), pages 419-423, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7334:d:10.1038_nature09672
    DOI: 10.1038/nature09672
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