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Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina

Author

Listed:
  • Ryota L. Matsuoka

    (The Johns Hopkins University School of Medicine
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine)

  • Kim T. Nguyen-Ba-Charvet

    (Institut National de la Santé et de la Recherche Médicale (INSERM), UMR S968, Institut de la Vision, F-75012 Paris, France
    Université Pierre et Marie Curie (UPMC) Paris VI, UMR S968, Institut de la Vision, F-75012 Paris, France
    Centre National de la Recherche Scientifique (CNRS) UMR 7210, Institut de la Vision, F-75012 Paris, France)

  • Aijaz Parray

    (Institut National de la Santé et de la Recherche Médicale (INSERM), UMR S968, Institut de la Vision, F-75012 Paris, France
    Université Pierre et Marie Curie (UPMC) Paris VI, UMR S968, Institut de la Vision, F-75012 Paris, France
    Centre National de la Recherche Scientifique (CNRS) UMR 7210, Institut de la Vision, F-75012 Paris, France)

  • Tudor C. Badea

    (The Johns Hopkins University School of Medicine
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine
    Present address: Retinal Circuit Development & Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, Bethesda, Maryland 20892, USA .)

  • Alain Chédotal

    (Institut National de la Santé et de la Recherche Médicale (INSERM), UMR S968, Institut de la Vision, F-75012 Paris, France
    Université Pierre et Marie Curie (UPMC) Paris VI, UMR S968, Institut de la Vision, F-75012 Paris, France
    Centre National de la Recherche Scientifique (CNRS) UMR 7210, Institut de la Vision, F-75012 Paris, France)

  • Alex L. Kolodkin

    (The Johns Hopkins University School of Medicine
    Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine)

Abstract

Molecular cue in the developing retina The retina is a laminated structure made up of several different cellular subtypes, interconnected according to a precise architecture that is vital for proper visual perception. Matsuoka et al. shed new light on the molecular mechanisms governing the development of these circuits. Transmembrane molecules — typically most active as repulsive signals during axonal guidance — exhibit specific expression patterns within the retina that promote appropriate connectivity between cell types. Mutant mice lacking specific isoforms of these semaphorin or plexin molecular families display significant defects in retinal circuitry. Thus, repulsive cues present on the neuronal processes themselves drive proper wiring between lamina within the retina.

Suggested Citation

  • Ryota L. Matsuoka & Kim T. Nguyen-Ba-Charvet & Aijaz Parray & Tudor C. Badea & Alain Chédotal & Alex L. Kolodkin, 2011. "Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina," Nature, Nature, vol. 470(7333), pages 259-263, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7333:d:10.1038_nature09675
    DOI: 10.1038/nature09675
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