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Structural basis for site-specific ribose methylation by box C/D RNA protein complexes

Author

Listed:
  • Jinzhong Lin

    (National Institute of Biological Sciences)

  • Shaomei Lai

    (National Institute of Biological Sciences)

  • Ru Jia

    (National Institute of Biological Sciences)

  • Anbi Xu

    (National Institute of Biological Sciences)

  • Liman Zhang

    (National Institute of Biological Sciences
    Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jing Lu

    (National Institute of Biological Sciences
    Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Keqiong Ye

    (National Institute of Biological Sciences)

Abstract

Target recognition by a guide RNA Some RNAs, called guide RNAs, use their encoded sequence information to help direct a protein to where it is required. One of these RNA-protein (RNP) complexes, known as the box C/D RNP, catalyses the site-specific modification of RNAs with a 2′-O-methylation group. The structure of the full box C/D RNP complex, including three protein subunits, the guide RNA and either of two substrate RNAs, has now been determined. The structure reveals how the guide and target RNAs are aligned, and how the methyltransferase subunit, fibrillarin, facilitates positioning of the target ribose into the active site.

Suggested Citation

  • Jinzhong Lin & Shaomei Lai & Ru Jia & Anbi Xu & Liman Zhang & Jing Lu & Keqiong Ye, 2011. "Structural basis for site-specific ribose methylation by box C/D RNA protein complexes," Nature, Nature, vol. 469(7331), pages 559-563, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7331:d:10.1038_nature09688
    DOI: 10.1038/nature09688
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