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Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

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  • Alastair S. Garfield

    (University of Bath, Claverton Down, Bath BA2 7AY, UK
    Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine and Psychology, Cardiff University, Cardiff CF14 4XN, UK
    Present address: Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.)

  • Michael Cowley

    (University of Bath, Claverton Down, Bath BA2 7AY, UK
    Present address:Department of Medical and Molecular Genetics, King’s College London, 8th Floor Tower Wing, Guy’s Hospital, London SE1 9RT, UK)

  • Florentia M. Smith

    (University of Bath, Claverton Down, Bath BA2 7AY, UK)

  • Kim Moorwood

    (University of Bath, Claverton Down, Bath BA2 7AY, UK)

  • Joanne E. Stewart-Cox

    (University of Bath, Claverton Down, Bath BA2 7AY, UK)

  • Kerry Gilroy

    (Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine and Psychology, Cardiff University, Cardiff CF14 4XN, UK)

  • Sian Baker

    (Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine and Psychology, Cardiff University, Cardiff CF14 4XN, UK)

  • Jing Xia

    (University of Cambridge, Downing Street, Cambridge CB2 3EB, UK)

  • Jeffrey W. Dalley

    (University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    University of Cambridge, Addenbrooke’s Hospital, Hill’s Road, Cambridge CB2 2QQ, UK)

  • Laurence D. Hurst

    (University of Bath, Claverton Down, Bath BA2 7AY, UK)

  • Lawrence S. Wilkinson

    (Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine and Psychology, Cardiff University, Cardiff CF14 4XN, UK)

  • Anthony R. Isles

    (Behavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Schools of Medicine and Psychology, Cardiff University, Cardiff CF14 4XN, UK)

  • Andrew Ward

    (University of Bath, Claverton Down, Bath BA2 7AY, UK)

Abstract

Like mother, like father Genetic imprinting — the preferential expression of a single parental allele — has typically been implicated as an influential factor during development, but whether unequal representation of one allele can influence social behaviour has not previously been studied. The adapter protein Grb10 is predominantly expressed from the maternal allele during embryogenesis. Here, Andrew Ward and colleagues demonstrate that Grb10 is predominantly expressed from the paternal allele in the brain from fetal life onwards, and that ablating this allelic bias induces modifications to social behaviour such as grooming. This is the first report of an imprinted gene for which tissue-specific actions of each parental allele can influence distinct physiological or behavioural processes.

Suggested Citation

  • Alastair S. Garfield & Michael Cowley & Florentia M. Smith & Kim Moorwood & Joanne E. Stewart-Cox & Kerry Gilroy & Sian Baker & Jing Xia & Jeffrey W. Dalley & Laurence D. Hurst & Lawrence S. Wilkinson, 2011. "Distinct physiological and behavioural functions for parental alleles of imprinted Grb10," Nature, Nature, vol. 469(7331), pages 534-538, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7331:d:10.1038_nature09651
    DOI: 10.1038/nature09651
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    Cited by:

    1. Samuel Sunghwan Cho & Yongkang Kim & Joon Yoon & Minseok Seo & Su-kyung Shin & Eun-Young Kwon & Sung-Eun Kim & Yun-Jung Bae & Seungyeoun Lee & Mi-Kyung Sung & Myung-Sook Choi & Taesung Park, 2016. "A Model-Based Joint Identification of Differentially Expressed Genes and Phenotype-Associated Genes," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-14, March.

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