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Autophagy in immunity and inflammation

Author

Listed:
  • Beth Levine

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center)

  • Noboru Mizushima

    (Tokyo Medical and Dental University)

  • Herbert W. Virgin

    (Washington University School of Medicine and Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Campus Box 8118, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA. virgin@wustl.edu)

Abstract

Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is adaptation to nutrient deprivation. However, in complex multicellular organisms, the core molecular machinery of autophagy — the 'autophagy proteins' — orchestrates diverse aspects of cellular and organismal responses to other dangerous stimuli such as infection. Recent developments reveal a crucial role for the autophagy pathway and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.

Suggested Citation

  • Beth Levine & Noboru Mizushima & Herbert W. Virgin, 2011. "Autophagy in immunity and inflammation," Nature, Nature, vol. 469(7330), pages 323-335, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7330:d:10.1038_nature09782
    DOI: 10.1038/nature09782
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    Cited by:

    1. Qiaona Wang & Ziling Xu & Ying Wang & Guangming Huo & Xing Zhang & Jianmei Li & Chun Hua & Shengjie Li & Feng Zhou, 2023. "Transcriptomics Analysis of the Toxicological Impact of Enrofloxacin in an Aquatic Environment on the Chinese Mitten Crab ( Eriocheir sinensis )," IJERPH, MDPI, vol. 20(3), pages 1-14, January.

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