Author
Listed:
- Mikel Zaratiegui
(Cold Spring Harbor Laboratory)
- Matthew W. Vaughn
(Cold Spring Harbor Laboratory
Present addresses: Texas Advanced Computing Center, University of Texas at Austin, 10100 Burnet Road, Austin, Texas 78758, USA (M.W.V.); Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children’s Hospital, Flemington Road, Parkville 3052, Australia (D.V.I.); Creative Research Initiative Sousei, Hokkaido University. North-21, West-10, Kita-ku, Sapporo, 001-0021, JAPAN (D.G.); Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK (S.W.).)
- Danielle V. Irvine
(Cold Spring Harbor Laboratory
Present addresses: Texas Advanced Computing Center, University of Texas at Austin, 10100 Burnet Road, Austin, Texas 78758, USA (M.W.V.); Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children’s Hospital, Flemington Road, Parkville 3052, Australia (D.V.I.); Creative Research Initiative Sousei, Hokkaido University. North-21, West-10, Kita-ku, Sapporo, 001-0021, JAPAN (D.G.); Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK (S.W.).)
- Derek Goto
(Cold Spring Harbor Laboratory
Present addresses: Texas Advanced Computing Center, University of Texas at Austin, 10100 Burnet Road, Austin, Texas 78758, USA (M.W.V.); Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children’s Hospital, Flemington Road, Parkville 3052, Australia (D.V.I.); Creative Research Initiative Sousei, Hokkaido University. North-21, West-10, Kita-ku, Sapporo, 001-0021, JAPAN (D.G.); Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK (S.W.).)
- Stephen Watt
(University College London, Evolution & Environment, and UCL Cancer Institute, Darwin Building
Present addresses: Texas Advanced Computing Center, University of Texas at Austin, 10100 Burnet Road, Austin, Texas 78758, USA (M.W.V.); Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Royal Children’s Hospital, Flemington Road, Parkville 3052, Australia (D.V.I.); Creative Research Initiative Sousei, Hokkaido University. North-21, West-10, Kita-ku, Sapporo, 001-0021, JAPAN (D.G.); Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK (S.W.).)
- Jürg Bähler
(University College London, Evolution & Environment, and UCL Cancer Institute, Darwin Building)
- Benoit Arcangioli
(Institut Pasteur, Dynamics of the Genome Unit, CNRS URA2171)
- Robert A. Martienssen
(Cold Spring Harbor Laboratory)
Abstract
Genome integrity at replication forks Previous studies have indicated an undefined role in DNA replication for CENP-B, a DNA-binding protein associated with heterochromatin, centromeres and retrotransposon long terminal repeats (LTRs). Robert Martienssen and colleagues show that Sap1, which binds LTRs, promotes genomic instability when CENP-B activity is absent. CENP-B facilitates replication-fork progression through LTRs in a way that protects against rearrangements.
Suggested Citation
Mikel Zaratiegui & Matthew W. Vaughn & Danielle V. Irvine & Derek Goto & Stephen Watt & Jürg Bähler & Benoit Arcangioli & Robert A. Martienssen, 2011.
"CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR,"
Nature, Nature, vol. 469(7328), pages 112-115, January.
Handle:
RePEc:nat:nature:v:469:y:2011:i:7328:d:10.1038_nature09608
DOI: 10.1038/nature09608
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