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Theobald reply

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  • D. L. Theobald

    (Brandeis University)

Abstract

Replying to T. Yonezawa & M. Hasegawa Nature 468, 10.1038/nature09482 (2010) Yonezawa and Hasegawa 1 provide an example from two apparently unrelated families of nucleic acid coding sequences for which an Akaike information criterion (AIC) model selection test, similar to mine2, chooses a common origin hypothesis. Although this may seem surprising, the coding sequences in this example were aligned in the same reading frame. The constraints of the genetic code are expected to induce correlations between these sequences (and among all coding sequences) that are not due to common ancestry. For instance, owing to codon bias and the structure of the genetic code, in these sequences the second codon position is biased towards T (about twofold over average), whereas the third position is usually an A (∼50%) and rarely a G (∼4%).

Suggested Citation

  • D. L. Theobald, 2010. "Theobald reply," Nature, Nature, vol. 468(7326), pages 10-10, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7326:d:10.1038_nature09483
    DOI: 10.1038/nature09483
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