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2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

Author

Listed:
  • Stephane Daffis

    (Washington University School of Medicine)

  • Kristy J. Szretter

    (Washington University School of Medicine)

  • Jill Schriewer

    (Saint Louis University School of Medicine)

  • Jianqing Li

    (Washington University School of Medicine)

  • Soonjeon Youn

    (Washington University School of Medicine)

  • John Errett

    (University of Washington School of Medicine)

  • Tsai-Yu Lin

    (Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health)

  • Stewart Schneller

    (Auburn University)

  • Roland Zust

    (Institute of Immunobiology, Kantonal Hospital St Gallen)

  • Hongping Dong

    (Wadsworth Center)

  • Volker Thiel

    (Institute of Immunobiology, Kantonal Hospital St Gallen
    Vetsuisse Faculty, University of Zürich)

  • Ganes C. Sen

    (Cleveland Clinic, Lerner Research Institute)

  • Volker Fensterl

    (Cleveland Clinic, Lerner Research Institute)

  • William B. Klimstra

    (University of Pittsburgh Medical School)

  • Theodore C. Pierson

    (Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health)

  • R. Mark Buller

    (Midwest, Pacific Northwest, and Northeast Regional Centers for Biodefense and Emerging Infectious Diseases Research
    Saint Louis University School of Medicine)

  • Michael Gale Jr

    (Midwest, Pacific Northwest, and Northeast Regional Centers for Biodefense and Emerging Infectious Diseases Research
    University of Washington School of Medicine)

  • Pei-Yong Shi

    (Midwest, Pacific Northwest, and Northeast Regional Centers for Biodefense and Emerging Infectious Diseases Research
    Wadsworth Center)

  • Michael S. Diamond

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    Midwest, Pacific Northwest, and Northeast Regional Centers for Biodefense and Emerging Infectious Diseases Research)

Abstract

Evasion of host antiviral mechanisms Many cellular messenger RNAs and viral RNAs are methylated at the 2′-O position of the 5′ guanosine cap. The role of this modification in virus infection has been unclear. Michael Diamond and colleagues now show that this form of methylation enables several unrelated viruses to evade innate host antiviral responses through escape from suppression by interferon-stimulated genes. This suggests an evolutionary explanation for 2′-O methylation of cellular mRNA: it may distinguish self from non-self RNA under conditions of infection. Novel classes of pharmacological agents that specifically inhibit cytoplasmic viral 2′-O methyltransferases may be expected to have broad-spectrum antiviral activity.

Suggested Citation

  • Stephane Daffis & Kristy J. Szretter & Jill Schriewer & Jianqing Li & Soonjeon Youn & John Errett & Tsai-Yu Lin & Stewart Schneller & Roland Zust & Hongping Dong & Volker Thiel & Ganes C. Sen & Volker, 2010. "2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members," Nature, Nature, vol. 468(7322), pages 452-456, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7322:d:10.1038_nature09489
    DOI: 10.1038/nature09489
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