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The mechanism of retroviral integration from X-ray structures of its key intermediates

Author

Listed:
  • Goedele N. Maertens

    (Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK)

  • Stephen Hare

    (Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK)

  • Peter Cherepanov

    (Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK)

Abstract

Retroviral integration mechanisms Retroviruses such as HIV need to insert their genome into the host genome in order to replicate. This process is mediated by a tetramer of the virus-encoded integrase protein. Earlier this year, Peter Cherepanov and colleagues reported the structure of a related integrase from prototype foamy virus bound to the cleaved viral DNA ends, a complex known as the intasome. Now they have solved the structure of the intasome interacting with the target host DNA, before and after it is cleaved. This work reveals new details of the integration process that could be useful in designing improved inhibitors of HIV.

Suggested Citation

  • Goedele N. Maertens & Stephen Hare & Peter Cherepanov, 2010. "The mechanism of retroviral integration from X-ray structures of its key intermediates," Nature, Nature, vol. 468(7321), pages 326-329, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09517
    DOI: 10.1038/nature09517
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    Cited by:

    1. Monica Naughtin & Zofia Haftek-Terreau & Johan Xavier & Sam Meyer & Maud Silvain & Yan Jaszczyszyn & Nicolas Levy & Vincent Miele & Mohamed Salah Benleulmi & Marc Ruff & Vincent Parissi & Cédric Vaill, 2015. "DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-28, June.
    2. Guillermo Abascal-Palacios & Laura Jochem & Carlos Pla-Prats & Fabienne Beuron & Alessandro Vannini, 2021. "Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    3. Gayan Senavirathne & James London & Anne Gardner & Richard Fishel & Kristine E. Yoder, 2023. "DNA strand breaks and gaps target retroviral intasome binding and integration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Allison Ballandras-Colas & Vidya Chivukula & Dominika T. Gruszka & Zelin Shan & Parmit K. Singh & Valerie E. Pye & Rebecca K. McLean & Gregory J. Bedwell & Wen Li & Andrea Nans & Nicola J. Cook & Hind, 2022. "Multivalent interactions essential for lentiviral integrase function," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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