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Myosin in motion

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  • Deepa Nath

Abstract

Walking myosin V caught on video Motor proteins of the myosin family serve many important functions in eukaryotic cells and are central to actin-based motility. Our understanding of the mechanism of myosin action has been hampered by the lack of technology for simultaneously observing the structure and dynamics of biomolecules, but now Kodera et al. have used high-speed atomic force microscopy (HS-AFM) to directly observe myosin V moving along actin filaments with unprecedented time resolution. They obtain high-resolution movies that provide visual evidence supporting the 'swinging lever-arm' model for myosin motility. The high-resolution imaging possible using HS-AFM should make the technique broadly applicable in the fields of structural biology and single-molecule biology.

Suggested Citation

  • Deepa Nath, 2010. "Myosin in motion," Nature, Nature, vol. 468(7320), pages 43-43, November.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7320:d:10.1038_468043a
    DOI: 10.1038/468043a
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