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Satellite phage TLCφ enables toxigenic conversion by CTX phage through dif site alteration

Author

Listed:
  • Faizule Hassan

    (Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh)

  • M. Kamruzzaman

    (Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh)

  • John J. Mekalanos

    (Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Shah M. Faruque

    (Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh)

Abstract

The evolution of virulent Vibrio cholerae It has been known since the 1990s that the cholera toxin genes in Vibrio cholerae are found in the integrated bacteriophage CTXΦ, located in the V. cholerae genome adjacent to toxin-linked cryptic (TLC), a chromosomal DNA element of unknown function. TLC is now shown to correspond to the genome of TLCΦ, a satellite filamentous phage that uses the morphogenesis genes of a third filamentous phage (fs2Φ) to form infectious particles. By reconstructing the events that lead to the acquisition of phage DNA and comparing these to the genome of pandemic strains, Hassan et al. obtain a model of how virulent V. cholerae strains evolve to become successful human pathogens.

Suggested Citation

  • Faizule Hassan & M. Kamruzzaman & John J. Mekalanos & Shah M. Faruque, 2010. "Satellite phage TLCφ enables toxigenic conversion by CTX phage through dif site alteration," Nature, Nature, vol. 467(7318), pages 982-985, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7318:d:10.1038_nature09469
    DOI: 10.1038/nature09469
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