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TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

Author

Listed:
  • Xiaohua Su

    (The University of Texas M. D. Anderson Cancer Center)

  • Deepavali Chakravarti

    (The University of Texas M. D. Anderson Cancer Center
    Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center)

  • Min Soon Cho

    (The University of Texas M. D. Anderson Cancer Center
    Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center)

  • Lingzhi Liu

    (The University of Texas M. D. Anderson Cancer Center)

  • Young Jin Gi

    (The University of Texas M. D. Anderson Cancer Center)

  • Yu-Li Lin

    (The University of Texas M. D. Anderson Cancer Center)

  • Marco L. Leung

    (The University of Texas M. D. Anderson Cancer Center)

  • Adel El-Naggar

    (The University of Texas M. D. Anderson Cancer Center)

  • Chad J. Creighton

    (Dan L. Duncan Cancer Center, Baylor College of Medicine)

  • Milind B. Suraokar

    (The University of Texas M. D. Anderson Cancer Center)

  • Ignacio Wistuba

    (The University of Texas M. D. Anderson Cancer Center)

  • Elsa R. Flores

    (The University of Texas M. D. Anderson Cancer Center
    Graduate School of Biomedical Sciences, The University of Texas M. D. Anderson Cancer Center)

Abstract

TAp63 tumour suppression via Dicer The endoribonuclease Dicer is a key factor in the production of microRNAs. The deregulation of microRNA expression and potentially Dicer itself have been implicated in cancer. Elsa Flores and colleagues now show that TAp63, a member of the p53 family of tumour suppressors, suppresses tumorigenesis and metastasis by directly controlling the expression of Dicer and Dicer-regulated microRNAs.

Suggested Citation

  • Xiaohua Su & Deepavali Chakravarti & Min Soon Cho & Lingzhi Liu & Young Jin Gi & Yu-Li Lin & Marco L. Leung & Adel El-Naggar & Chad J. Creighton & Milind B. Suraokar & Ignacio Wistuba & Elsa R. Flores, 2010. "TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs," Nature, Nature, vol. 467(7318), pages 986-990, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7318:d:10.1038_nature09459
    DOI: 10.1038/nature09459
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