IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v467y2010i7318d10.1038_nature09421.html
   My bibliography  Save this article

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

Author

Listed:
  • Xiaoxia Z. West

    (J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation
    Case Western Reserve University)

  • Nikolay L. Malinin

    (J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation)

  • Alona A. Merkulova

    (J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation)

  • Mira Tischenko

    (J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation)

  • Bethany A. Kerr

    (J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation)

  • Ernest C. Borden

    (Taussig Cancer Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA)

  • Eugene A. Podrez

    (J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation)

  • Robert G. Salomon

    (Case Western Reserve University)

  • Tatiana V. Byzova

    (J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation
    Taussig Cancer Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA)

Abstract

TLR2 links immunity, oxidation and angiogenesis Inflammation is known to cause oxidative stress and the growth of new blood vessels, and now a molecular mechanism linking these processes has been found. Oxidized products of lipid oxidation — (carboxy alkyl)pyrrole protein adducts — are generated during inflammation and wound healing. These products are shown to act as endogenous agonists for Toll-like receptor 2 (TLR2), which stimulates blood vessel growth through a mechanism that is independent of vascular endothelial growth factor. This work establishes a new function for TLR2 as a sensor of oxidation-associated molecular patterns, providing a link connecting inflammation, oxidative stress, innate immunity and angiogenesis.

Suggested Citation

  • Xiaoxia Z. West & Nikolay L. Malinin & Alona A. Merkulova & Mira Tischenko & Bethany A. Kerr & Ernest C. Borden & Eugene A. Podrez & Robert G. Salomon & Tatiana V. Byzova, 2010. "Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands," Nature, Nature, vol. 467(7318), pages 972-976, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7318:d:10.1038_nature09421
    DOI: 10.1038/nature09421
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09421
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09421?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:467:y:2010:i:7318:d:10.1038_nature09421. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.