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Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst

Author

Listed:
  • Annabel Guichard

    (Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0349, USA)

  • Shauna M. McGillivray

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0687, USA
    Texas Christian University, 2800 South University Drive)

  • Beatriz Cruz-Moreno

    (Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0349, USA)

  • Nina M. van Sorge

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0687, USA)

  • Victor Nizet

    (University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0687, USA
    Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0687, USA)

  • Ethan Bier

    (Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0349, USA)

Abstract

Mechanism of action of anthrax toxins The pathogen Bacillus anthracis secretes two potent toxins during anthrax infection, known as lethal factor (LF) and oedema factor (EF). Using transgenic Drosophila as a model system for the identification of pathways that might be involved in anthrax pathogenesis, Ethan Bier and colleagues show that these two toxins interact synergistically to block Rab11/Sec15 exocyst-dependent endocytic recycling, resulting in reduced Notch signalling and cadherin-dependent adhesion at the adherens junction. Tests in human endothelial cells indicate that the toxins have a similar effect on Rab11/Sec15 activity and Notch signalling.

Suggested Citation

  • Annabel Guichard & Shauna M. McGillivray & Beatriz Cruz-Moreno & Nina M. van Sorge & Victor Nizet & Ethan Bier, 2010. "Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst," Nature, Nature, vol. 467(7317), pages 854-858, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7317:d:10.1038_nature09446
    DOI: 10.1038/nature09446
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