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Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1

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  • Jun Arii

    (International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
    Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan)

  • Hideo Goto

    (The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Tadahiro Suenaga

    (Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan)

  • Masaaki Oyama

    (Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Hiroko Kozuka-Hata

    (Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Takahiko Imai

    (International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Atsuko Minowa

    (International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

  • Hiroomi Akashi

    (Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan)

  • Hisashi Arase

    (Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan
    WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan)

  • Yoshihiro Kawaoka

    (The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
    International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
    University of Wisconsin-Madison
    ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan)

  • Yasushi Kawaguchi

    (International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan)

Abstract

A herpes simplex virus-1 entry protein The entry of herpes simplex virus-1 (HSV-1) into cells requires the presence of cellular receptors for both envelope glycoproteins B and D. Now a proteomics-based search for further molecules interacting with HSV-1 has identified non-muscle myosin heavy chain IIA (NMHC-IIA) as a functional entry receptor, acting together with glycoprotein D. NMHC-IIA knockdown reduces HSV-1 infection in cell culture and a mouse model, suggesting that drugs or vaccines that target NMHC-IIA and non-muscle myosin IIA regulators may be effective against herpes infections.

Suggested Citation

  • Jun Arii & Hideo Goto & Tadahiro Suenaga & Masaaki Oyama & Hiroko Kozuka-Hata & Takahiko Imai & Atsuko Minowa & Hiroomi Akashi & Hisashi Arase & Yoshihiro Kawaoka & Yasushi Kawaguchi, 2010. "Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1," Nature, Nature, vol. 467(7317), pages 859-862, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7317:d:10.1038_nature09420
    DOI: 10.1038/nature09420
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