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Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

Author

Listed:
  • Faraaz B. Chekeni

    (Beirne B. Carter Center for Immunology Research,
    University of Virginia, Charlottesville, Virginia 22908, USA)

  • Michael R. Elliott

    (Beirne B. Carter Center for Immunology Research,
    The Center for Cell Clearance, University of Virginia)

  • Joanna K. Sandilos

    (University of Virginia, Charlottesville, Virginia 22908, USA)

  • Scott F. Walk

    (Beirne B. Carter Center for Immunology Research,
    The Center for Cell Clearance, University of Virginia)

  • Jason M. Kinchen

    (Beirne B. Carter Center for Immunology Research,
    The Center for Cell Clearance, University of Virginia
    University of Virginia)

  • Eduardo R. Lazarowski

    (University of North Carolina)

  • Allison J. Armstrong

    (Beirne B. Carter Center for Immunology Research,
    The Center for Cell Clearance, University of Virginia)

  • Silvia Penuela

    (University of Western Ontario)

  • Dale W. Laird

    (University of Western Ontario)

  • Guy S. Salvesen

    (Program in Apoptosis and Cell Death Research, The Burnham Institute for Medical Research)

  • Brant E. Isakson

    (University of Virginia)

  • Douglas A. Bayliss

    (University of Virginia, Charlottesville, Virginia 22908, USA)

  • Kodi S. Ravichandran

    (Beirne B. Carter Center for Immunology Research,
    The Center for Cell Clearance, University of Virginia
    University of Virginia)

Abstract

Pannexin 1 helps attract phagocytes Apoptotic cells were shown recently to discharge the nucleotides ATP and UTP to act as 'find-me' signals for phagocytes that engulf dying cells before they release potentially harmful cellular contents. This paper shows that the release of ATP and UTP is through the plasma membrane channel pannexin 1, which is specifically opened by caspase activity. The discovery of a role for pannexin 1 in phagocyte chemoattraction could have implications for human diseases that arise from defective clearance of dying cells.

Suggested Citation

  • Faraaz B. Chekeni & Michael R. Elliott & Joanna K. Sandilos & Scott F. Walk & Jason M. Kinchen & Eduardo R. Lazarowski & Allison J. Armstrong & Silvia Penuela & Dale W. Laird & Guy S. Salvesen & Brant, 2010. "Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis," Nature, Nature, vol. 467(7317), pages 863-867, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7317:d:10.1038_nature09413
    DOI: 10.1038/nature09413
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