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ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours

Author

Listed:
  • Ping Chi

    (Memorial Sloan-Kettering Cancer Center
    Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University)

  • Yu Chen

    (Memorial Sloan-Kettering Cancer Center
    Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Lei Zhang

    (Memorial Sloan-Kettering Cancer Center)

  • Xingyi Guo

    (Albert Einstein College of Medicine, Bronx, New York, 10461 USA)

  • John Wongvipat

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Tambudzai Shamu

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Jonathan A. Fletcher

    (Brigham and Women’s Hospital)

  • Scott Dewell

    (Genomics Resource Center, The Rockefeller University)

  • Robert G. Maki

    (Memorial Sloan-Kettering Cancer Center)

  • Deyou Zheng

    (Albert Einstein College of Medicine, Bronx, New York, 10461 USA
    Albert Einstein College of Medicine)

  • Cristina R. Antonescu

    (Memorial Sloan-Kettering Cancer Center)

  • C. David Allis

    (Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University)

  • Charles L. Sawyers

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
    Howard Hughes Medical Institute)

Abstract

ETV1: a factor in gastrointestinal cancer Gastroinestinal stromal tumours (GISTs) arise in the interstitial cells of Cajal, cells embedded in the musculature of the gastrointestinal tract where they generate electrical rhythmicity. Chi et al. now show that the transcription factor ETV1 is required for the development of these cells, and also promotes tumour development. The KIT gene, often activated by mutations in GIST, cooperates with ETV1 in the transformation of interstitial cells of Cajal, in part by promoting ETV1 stabilization. ETV1 seems to be present in high levels in all GISTs, making it a candidate diagnostic biomarker, and ETV1 blockers may prove useful against drug-resistant GIST.

Suggested Citation

  • Ping Chi & Yu Chen & Lei Zhang & Xingyi Guo & John Wongvipat & Tambudzai Shamu & Jonathan A. Fletcher & Scott Dewell & Robert G. Maki & Deyou Zheng & Cristina R. Antonescu & C. David Allis & Charles L, 2010. "ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours," Nature, Nature, vol. 467(7317), pages 849-853, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7317:d:10.1038_nature09409
    DOI: 10.1038/nature09409
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    Cited by:

    1. Carlos Olmeda-Gómez & Carlos Romá-Mateo & Maria-Antonia Ovalle-Perandones, 2019. "Overview of trends in global epigenetic research (2009–2017)," Scientometrics, Springer;Akadémiai Kiadó, vol. 119(3), pages 1545-1574, June.

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