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Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation

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  • Tatsuya Tsukahara

    (Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113-0032, Japan
    Graduate Program in Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Yayoi, Tokyo 113-0032, Japan)

  • Yuji Tanno

    (Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113-0032, Japan)

  • Yoshinori Watanabe

    (Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113-0032, Japan
    Graduate Program in Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Yayoi, Tokyo 113-0032, Japan)

Abstract

Chromosome bi-orientation The chromosomal passenger complex (CPC) coordinates several processes during cell division, including chromosome bi-orientation and cytokinesis, and proper localization of this complex is crucial for its diverse functions. In this study, Yoshinori Watanabe and colleagues provide a mechanism for the localization of the CPC to the inner centromere. Cdk1–cyclin-B-dependent phosphorylation of the CPC promotes binding to shugoshin, which the authors now define as a conserved centromeric adaptor of the CPC. This mechanism is conserved between fission yeast and human cells and highlights a crucial role of Cdk1–cyclin B in chromosome bi-orientation.

Suggested Citation

  • Tatsuya Tsukahara & Yuji Tanno & Yoshinori Watanabe, 2010. "Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation," Nature, Nature, vol. 467(7316), pages 719-723, October.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7316:d:10.1038_nature09390
    DOI: 10.1038/nature09390
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