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Identification of a quality-control mechanism for mRNA 5′-end capping

Author

Listed:
  • Xinfu Jiao

    (Rutgers University)

  • Song Xiang

    (Columbia University)

  • ChanSeok Oh

    (Rutgers University)

  • Charles E. Martin

    (Rutgers University)

  • Liang Tong

    (Columbia University)

  • Megerditch Kiledjian

    (Rutgers University)

Abstract

Quality control for mRNA Following their transcription, eukaryotic messenger RNAs have a 7-methylguanosine cap added to their 5′ ends to protect the mRNA from degradation. Xinfu Jiao et al. show that caps lacking a methyl group are recognized by Rai1, which clips off the incomplete cap. These data suggest that Rai1 is part of a quality-control mechanism that monitors and promotes the digestion of aberrant mRNAs that may arise during stress conditions.

Suggested Citation

  • Xinfu Jiao & Song Xiang & ChanSeok Oh & Charles E. Martin & Liang Tong & Megerditch Kiledjian, 2010. "Identification of a quality-control mechanism for mRNA 5′-end capping," Nature, Nature, vol. 467(7315), pages 608-611, September.
    • Handle: RePEc:nat:nature:v:467:y:2010:i:7315:d:10.1038_nature09338
    DOI: 10.1038/nature09338
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